Adelson program in neural repair and rehabilitation

The fact that the adult brain is capable of axonal sprouting and neurogenesis after stroke indicates that stroke induces a region of great structural change, or plasticity, near areas of damage. In a third avenue of investigation, my laboratory is identifying these areas of brain plasticity after stroke as candidate regions for neural stem cell transplantation to promote recovery and restoration of function after stroke.

This novel environment is induced by stroke in the tissue that surrounds the infarct or stroke site. In this region, new blood vessels are formed, and secrete growth factors that stimulate neural stem cells to become neurons.

Also, within this regenerative brain environment after stroke, molecules are expressed that promote the formation of new connections, or axonal sprouting. Thomas Carmichael, M. In a school board meeting on Jan. Nina Dobrev looks totally toned in a new bikini video on Instagram. The actress, 33, says portion control has played a big role in her fitness revamp.

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Our work will identify the molecular mechanisms underlying neurodegeneration and investigate how they differ from normal aging. Using single-cell multi-omic approaches coupled with bulk tissue sequencing, we hope to directly answer some of these questions.

We are using multistage, systems biology approaches to elucidate the disease mechanisms in neurodegeneration. We identify two gene co-expression modules that are preserved in mice harboring mutations in MAPT, GRN and other dementia mutations on diverse genetic backgrounds. We bridge the species divide via integration with proteomic and transcriptomic data from the human brain to identify evolutionarily conserved, disease-relevant networks. We find that overexpression of miR, a hub of a putative regulatory microRNA miRNA module, recapitulates mRNA co-expression patterns associated with disease state and induces neuronal cell death, establishing this miRNA as a regulator of neurodegeneration.

Using a database of drug-mediated gene expression changes, we identify HDAC inhibitors that can normalize the disease-associated modules and validate this experimentally. Our results highlight the utility of an integrative, cross-species network approach Swarup et al. Med, We are using systems biology approaches to understand the transcriptomic and proteomic changes happening during nerve injury both in the peripheral and central nervous system. While the regeneration capacity of injured neuron in the central nervous system CNS is limited, peripheral nervous system PNS maintain some capacity to regenerate.

Using genomic approaches, we are trying to understand the temporal changes happening in PNS and CNS neurons after injury. Working with Adelson Program in Neural Repair and Rehabilitation APNRR researchers, we are also interested in unravel core regulators of neuronal regeneration and find novel drug targets to promote regeneration. Epub May 2. Revealing the brain's molecular architecture. Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.

Nat Med. Epub Dec 3. Inducible and reversible phenotypes in a novel mouse model of Friedreich's Ataxia. Epub Aug Cell Syst. Epub Dec Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism.

Epub Dec 5. Erratum in: Nature. Swarup V, Geschwind DH. Alzheimer's disease: From big data to mechanism. Epub Jul